Mercedes Sprinter Engine Oil Cooler – OEM-Equivalent | OM642 3.0L V6 | #6421800165 (2010–2021)

DESCRIPTION:

The engine oil cooler on the OM642 3.0L V6 is one of the most well-documented failure points on the entire Sprinter platform. When the cooler or its seals fail, engine oil and coolant mix — and the consequences range from costly to catastrophic. This OEM-equivalent replacement oil cooler restores proper oil temperature regulation and eliminates the risk of cross-contamination before it reaches your engine, at a more accessible price point than the Genuine OEM unit.

What This Part Does

The engine oil cooler uses engine coolant to regulate oil temperature, keeping oil viscosity stable under heavy loads and preventing overheating in the lubrication circuit. It mounts directly to the engine block as part of the oil filter housing assembly. When the internal seals degrade — a common occurrence on high-mileage OM642 engines — coolant enters the oil circuit or vice versa, leading to milky oil, coolant loss, and potential engine damage.

Common Signs of Oil Cooler Failure

• Milky or foamy oil on the dipstick or oil cap
• Unexplained coolant loss with no visible external leak
• White residue in the coolant reservoir
• Oil contamination in the coolant system

Service Tip

Always replace the oil cooler seals and gaskets (part #6421880580) at the same time as the cooler — reusing old seals on a new unit is one of the most common causes of post-repair leaks. Thoroughly flush both the oil and coolant circuits before returning the engine to service.

Fitment

• 2010–2021 Mercedes-Benz Sprinter 2500 – 3.0L V6 Diesel (OM642)
• 2010–2021 Mercedes-Benz Sprinter 3500 – 3.0L V6 Diesel (OM642)
• 2019–2020 Mercedes-Benz Sprinter 3500XD – 3.0L V6 Diesel (OM642)
• 2007–2009 Dodge/Freightliner Sprinter 2500/3500 – 3.0L V6 Diesel (OM642)

Always verify your VIN before ordering. Contact us and we'll confirm fitment before you buy.

Part Numbers

• Mercedes OEM Reference: 6421800165 / A6421800165 / 642-180-01-65
• SKU: 6421800165OE
• Related: Oil Cooler Gasket Kit #6421880580